FOR UK HEALTHCARE PROFESSIONALS

For more information about Cetraxal®, please see the prescribing information.

Acute Otitis Externa (AOE)
Definition: An inflammation of the external ear canal that has lasted for 3 weeks or less.

Symptoms:

  • Otalgia
  • Itching
  • Fullness
  • Hearing loss
  • Otorrhoea

AOE:

  • affects up to 10% of the population at some point in their lives1
  • is mostly caused by bacterial infection, with Pseudomonas aeruginosa and Staphylococcus aureus being most commonly isolated2
  • is also known as ‘swimmer’s ear’
    • Frequent exposure to water can alter the pH of the cerumen, increasing the likelihood of bacterial infections1

The Cetraxal range provides a non-ototoxic treatment option and may offer an alternative where antibiotic resistance is a complication

Ototoxicity
Definition: A pharmacological adverse reaction affecting the inner ear or auditory nerve, characterized by cochlear or vestibular dysfunction3.

Aminoglycosides are well known to cause ototoxicity4:

  • Gentamicin: vestibulotoxic5
    • Can result in dizziness, ataxia and nystagmus
  • Neomycin: cochleotoxic5
    • Can lead to permanent hearing loss

Fluoroquinolones eg. Cetraxal range are considered to be non-ototoxic6

Fight the fight against AOE

1. Rosenfeld M et al. Clinical practice guideline: acute otitis externa Otolaryngology Head Neck Surg 2014.
2. Roland P. et al Microbiology of acute otitis externa. Laryngoscope. 2002;112(7):1166–77.
3. Ganesan, P. et al. (2018) Ototoxicity: A Challenge in Diagnosis and Treatment. JAudiol Otol. 2018 Apr; 22(2): 59–68
4. Bitner-Glindzicz, M. et al. Ototoxicity caused by aminoglycosides. BMJ. 2007 Oct 20; 335(7624): 784–785.
5. Huth, M.E. et al. (2011) Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection. Int J Otolaryngol. 2011: 937861.
6. Coates, H. Ear drops and ototoxicity. Aust Prescr 2008; 31:40-1.
TRUSTED BRANDS.
DEPENDABLE SUPPLY CHAIN.
For further information please call: 01730 231148,
email: [email protected] or visit www.aspirepharma.co.uk
Adverse events should be reported. Reporting forms and information can be found at:

Adverse events should also be reported to Aspire Pharma Ltd on 01730 231148.www.mhra.gov.uk/yellowcard

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